CRISPR Screens Reveal Synthetic-Lethal Targets in KRAS-Mutant Tumours

Authors

  • Priya Nair Centre for Functional Genomics, Bengaluru Author

Keywords:

oncology, synthetic lethality, biomarkers, genomics, precision oncology, single-cell sequencing, CRISPR screening, precision medicine, targeted therapy, drug resistance, clonal evolution, tumour heterogeneity, tumour suppressor, oncogene

Abstract

KRAS-mutant cancers remain difficult to treat. We performed genome-wide CRISPR knockout screens across 28 KRAS-mutant tumour models to map synthetic-lethal dependencies.

We identified recurrent vulnerabilities in DNA-replication and metabolic pathways, providing genomics-guided combination strategies for precision oncology.

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CRISPR Screens Reveal Synthetic-Lethal Targets in KRAS-Mutant Tumours

Published

2026-06-08

Issue

Vol. 24 No. 6 (2026)

Section

Research Articles