Open Journal System Demo: Genomic Oncology

Research Articles

• Genome-Wide Methylation Landscape Identifies Drivers of Early Carcinogenesis

  Eleanor Whitfield, Hiroshi Sato (Author)

  Aberrant DNA methylation is an early hallmark of malignant transformation. We profiled the genome-wide methylation landscape of 480 pre-malignant and tumour...

  2026-06-04 Read Article →

• Targeting Drug-Tolerant Persister Cells in Lung Adenocarcinoma

  Marcus Bennett (Author)

  A subpopulation of drug-tolerant persister cells underlies relapse after targeted therapy. We characterised persister states in lung adenocarcinoma using...

  2026-06-05 Read Article →

• Single-Cell Genomics Reveals Clonal Evolution in Colorectal Tumours

  Aisha Rahman (Author)

  Intratumoural heterogeneity shapes treatment response. We applied single-cell DNA and RNA sequencing to 36 colorectal tumours spanning disease stages....

  2026-06-06 Read Article →

• Next-Generation Sequencing of Circulating Tumour DNA for Early Detection

  David Okonkwo (Author)

  Circulating tumour DNA enables non-invasive cancer detection. We developed a next-generation sequencing assay targeting methylation and mutation signals...

  2026-06-07 Read Article →

• Loss of Tumour Suppressor p53 Drives Genomic Instability

  Sofia Lindqvist (Author)

  The tumour suppressor p53 safeguards genome integrity. We modelled p53 loss in organoids and tracked the emergence of structural variation. p53 deficiency...

  2026-06-08 Read Article →

• Epigenetic Reprogramming of the Tumour Microenvironment

  Ingrid Moreau (Author)

  The tumour microenvironment is epigenetically remodelled during progression. We mapped methylation changes in stromal and immune compartments of breast...

  2026-06-09 Read Article →

• Oncogene Addiction and Synthetic Lethality in BRCA-Mutant Cancers

  Elena Petrova (Author)

  Synthetic lethality exploits tumour-specific dependencies. We performed genome-wide CRISPR screens in BRCA-mutant cancer lines to map DNA-repair...

  2026-06-10 Read Article →

• DNA Repair Deficiency as a Predictive Biomarker for Immunotherapy

  Yuki Tanaka (Author)

  Mismatch-repair deficiency predicts immunotherapy benefit, but finer stratification is needed. We analysed DNA-repair signatures across 2,400 treated...

  2026-06-11 Read Article →

• Mechanisms of Apoptosis Evasion in Treatment-Resistant Carcinoma

  Carlos Mendez (Author)

  Evasion of apoptosis is a core hallmark of cancer and a driver of therapy resistance. We dissected apoptotic priming in matched pre- and post-treatment...

  2026-06-12 Read Article →

• A Polygenic Risk Model for Hereditary Cancer Syndromes

  Lena Hoffmann (Author)

  Polygenic background modifies penetrance in hereditary cancer. We built a polygenic risk model in 18,000 carriers of high-penetrance variants. Polygenic...

  2026-06-13 Read Article →

• Telomere Dysfunction Drives Chromosomal Instability in Aggressive Carcinomas

  Yuki Tanaka, Laura Esposito (Author)

  Telomere attrition precipitates a state of chromosomal instability that fuels tumour heterogeneity. We characterised telomere dynamics across 312 aggressive...

  2026-06-07 Read Article →

• CRISPR Screens Reveal Synthetic-Lethal Targets in KRAS-Mutant Tumours

  Priya Nair (Author)

  KRAS-mutant cancers remain difficult to treat. We performed genome-wide CRISPR knockout screens across 28 KRAS-mutant tumour models to map synthetic-lethal...

  2026-06-08 Read Article →