DNA Repair Deficiency as a Predictive Biomarker for Immunotherapy

Authors

  • Yuki Tanaka Cancer Immunogenomics, Kyoto Author

Keywords:

DNA repair, biomarkers, immunotherapy, oncology, angiogenesis, cell cycle, chromatin remodelling, histone modification, mutational signature, copy-number variation, microsatellite instability, tumour suppressor, oncogene

Abstract

Mismatch-repair deficiency predicts immunotherapy benefit, but finer stratification is needed. We analysed DNA-repair signatures across 2,400 treated patients.

A composite DNA-repair deficiency score outperformed tumour mutational burden in predicting durable response, refining biomarker-driven patient selection.

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DNA Repair Deficiency as a Predictive Biomarker for Immunotherapy

Published

2026-06-11

Issue

Vol. 24 No. 6 (2026)

Section

Research Articles