Loss of Tumour Suppressor p53 Drives Genomic Instability

Authors

  • Sofia Lindqvist Cancer Cell Biology, Karolinska Author

Keywords:

p53, tumour suppressor, genomic instability, carcinogenesis, immunotherapy, tumour suppressor, oncogene, p53, BRCA1, KRAS, EGFR

Abstract

The tumour suppressor p53 safeguards genome integrity. We modelled p53 loss in organoids and tracked the emergence of structural variation.

p53 deficiency licensed chromothripsis and whole-genome doubling within ten passages, mechanistically linking tumour-suppressor loss to the genomic instability of carcinogenesis.

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Loss of Tumour Suppressor p53 Drives Genomic Instability

Published

2026-06-08

Issue

Vol. 24 No. 6 (2026)

Section

Research Articles