Next-Generation Sequencing of Circulating Tumour DNA for Early Detection

Authors

  • David Okonkwo Liquid Biopsy Centre, Toronto Author

Keywords:

next-generation sequencing, biomarkers, oncology, early detection, transcriptomics, DNA repair, somatic mutation, immunotherapy, tumour suppressor, oncogene, p53

Abstract

Circulating tumour DNA enables non-invasive cancer detection. We developed a next-generation sequencing assay targeting methylation and mutation signals across 1,100 plasma samples.

The assay detected stage I–II cancers with 78% sensitivity at 99% specificity, supporting ctDNA as a scalable biomarker for population screening.

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Next-Generation Sequencing of Circulating Tumour DNA for Early Detection

Published

2026-06-07

Issue

Vol. 24 No. 6 (2026)

Section

Research Articles