Oncogene Addiction and Synthetic Lethality in BRCA-Mutant Cancers

Authors

  • Elena Petrova Molecular Therapeutics, Berlin Author

Keywords:

oncogene, synthetic lethality, BRCA, DNA repair, EGFR, apoptosis, metastasis, angiogenesis, cell cycle, chromatin remodelling, histone modification, p53, BRCA1

Abstract

Synthetic lethality exploits tumour-specific dependencies. We performed genome-wide CRISPR screens in BRCA-mutant cancer lines to map DNA-repair vulnerabilities.

Beyond PARP, we identified polymerase theta as a synthetic-lethal target, offering a strategy to overcome resistance in homologous-recombination-deficient cancers.

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Oncogene Addiction and Synthetic Lethality in BRCA-Mutant Cancers

Published

2026-06-10

Issue

Vol. 24 No. 6 (2026)

Section

Research Articles